3,561 research outputs found

    Therapeutic and Radiosensitizing Effects of Armillaridin on Human Esophageal Cancer Cells

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    Background. Armillaridin (AM) is isolated from Armillaria mellea. We examined the anticancer activity and radiosensitizing effect on human esophageal cancer cells. Methods. Human squamous cell carcinoma (CE81T/VGH and TE-2) and adenocarcinoma (BE-3 and SKGT-4) cell lines were cultured. The MTT assay was used for cell viability. The cell cycle was analyzed using propidium iodide staining. Mitochondrial transmembrane potential was measured by DiOC6(3) staining. The colony formation assay was performed for estimation of the radiation surviving fraction. Human CE81T/VGH xenografts were established for evaluation of therapeutic activity in vivo. Results. AM inhibited the viability of four human esophageal cancer cell lines with an estimated concentration of 50% inhibition (IC50) which was 3.4–6.9 μM. AM induced a hypoploid cell population and morphological alterations typical of apoptosis in cells. This apoptosis induction was accompanied by a reduction of mitochondrial transmembrane potential. AM accumulated cell cycle at G2/M phase and enhanced the radiosensitivity in CE81T/VGH cells. In vivo, AM inhibited the growth of CE81T/VGH xenografts without significant impact on body weight and white blood cell counts. Conclusion. Armillaridin could inhibit growth and enhance radiosensitivity of human esophageal cancer cells. There might be potential to integrate AM with radiotherapy for esophageal cancer treatment

    Low-energy electronic recoil in xenon detectors by solar neutrinos

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    Low-energy electronic recoil caused by solar neutrinos in multi-ton xenon detectors is an important subject not only because it is a source of the irreducible background for direct searches of weakly-interacting massive particles (WIMPs), but also because it provides a viable way to measure the solar pppp and 7Be^{7}\textrm{Be} neutrinos at the precision level of current standard solar model predictions. In this work we perform ab initio\textit{ab initio} many-body calculations for the structure, photoionization, and neutrino-ionization of xenon. It is found that the atomic binding effect yields a sizable suppression to the neutrino-electron scattering cross section at low recoil energies. Compared with the previous calculation based on the free electron picture, our calculated event rate of electronic recoil in the same detector configuration is reduced by about 25%25\%. We present in this paper the electronic recoil rate spectrum in the energy window of 100 eV - 30 keV with the standard per ton per year normalization for xenon detectors, and discuss its implication for low energy solar neutrino detection (as the signal) and WIMP search (as a source of background).Comment: 12 pages, 3 figure

    Atomic ionization by sterile-to-active neutrino conversion and constraints on dark matter sterile neutrinos with germanium detectors

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    The transition magnetic moment of a sterile-to-active neutrino conversion gives rise to not only radiative decay of a sterile neutrino, but also its non-standard interaction (NSI) with matter. For sterile neutrinos of keV-mass as dark matter candidates, their decay signals are actively searched for in cosmic X-ray spectra. In this work, we consider the NSI that leads to atomic ionization, which can be detected by direct dark matter experiments. It is found that this inelastic scattering process for a nonrelativistic sterile neutrino has a pronounced enhancement in the differential cross section at energy transfer about half of its mass, manifesting experimentally as peaks in the measurable energy spectra. The enhancement effects gradually smear out as the sterile neutrino becomes relativistic. Using data taken with germanium detectors that have fine energy resolution in keV and sub-keV regimes, constraints on sterile neutrino mass and its transition magnetic moment are derived and compared with those from astrophysical observations

    Coronary Artery Ectasia Presenting With Recurrent Inferior Wall Myocardial Infarction

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    AbstractCoronary ectasia presenting as a recurrent inferior myocardial infarction has rarely been reported in the literature. Herein, we report a 61-year-old man who presented with persistent chest pain accompanied by ST segment elevation in the inferior ECG leads. Coronary angiography showed ectasia of the right coronary artery (RCA) and total occlusion from the middle RCA. Two stents were implanted separately in the middle and distal RCA. The patient was readmitted due to recurrent inferior wall infarction 15 months after discharge. He underwent primary percutaneous coronary intervention again, and coronary angiography showed massive thrombosis and in-stent re-stenosis. The thrombosis and re-stenosis were successfully treated using balloon angioplasty. The patient was discharged under medical therapy with aspirin and clopidogrel. There were no anginal symptoms during the 3 years of follow up

    A SMIL-Based Catalog Presentation System in Electronic Commerce

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    Web-based catalog presentations play the key-enabling role in E-commerce in recent years. Existing catalog systems often acquire proprietary platforms, cannot deal with TV-like media objects, or consume network bandwidth inefficiently. With the emergence of advanced technologies of Web and multimedia, such hurdles can be removed. The Synchronized Multimedia Integration Language (SMIL), proposed by W3C allows Web designers to design complicated and vivid multimedia presentations in a declarative manner. These presentations are then rendered on a general-purpose browser by a SMIL player. Since the SMIL specification is quite new to the Internet and E-commerce societies, the functionality and applications of players is limited. In this paper, we propose a novel architecture based on Java JMF technology for tackling with such constraints. The effectiveness of the proposed system is validated through an experiment on product catalog presentations

    Interpersonal Relationships among University Safety Professionals: The Impact of a Safety Departmentf

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    PresentationForming strong interpersonal relationships enables an organization or individual to achieve more favorable outcomes. The objectives of this study were to examine the frequency of interpersonal interactions among safety professionals (SPs) employed at Taiwanese universities and the factors that affected this frequency. To accomplish these objectives, we mailed questionnaires to a simple random sampling of 200 university SPs. Moreover, an interpersonal relationship scale was developed in this study; exploratory factor and internal consistency analyses revealed that the scale was valid and reliable. Results derived from the questionnaire revealed that in SP interpersonal relationships, general affairs department personnel, laboratory or internship unit supervisors, and teaching staff ranked highest in frequency of interactions. Multivariate analysis of variance results showed that establishing a safety department exerted a statistically significant effect on SP interpersonal relationships. SPs employed by universities with safety departments interacted more frequently with both internal and external relationships. Therefore, we suggest that universities without a safety department establish such a department to strengthen the labor safety and health structure, thereby benefitting SPs in fulfilling responsibilities to promote safety and health management
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